Autoimmune connective tissue diseases are a group of disorders in which the immune system mistakenly attacks protein-rich tissue that supports organs and other parts of the body, such as fat, bone and cartilage. These conditions may often affect the joints, muscles, skin, blood vessels, eyes, heart, lungs, kidneys and gastrointestinal tract. Frequently, the first presentation of the disease is in the skin, allowing the dermatologist to make an early diagnosis. Early diagnosis and intervention is important to prevent long term sequelae of the disease. Examples include lupus erythematosus, dermatomyositis, morphea, Sjogren syndrome and vasculitis. To offer the best care to our patients with these disorders, we collaborate with our colleagues in other specialties including Rheumatology, Gastroenterology and Nephrology in diagnosis and co-management of the condition.